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Ergebnisse 3 Einträge
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This functional magnetic resonance imaging study investigated the disgust- and fear-reactivity of patients suffering from obsessive-compulsive disorder (OCD). Ten OCD patients were scanned while viewing blocks of pictures showing OCD triggers from their personal environment and OCD-irrelevant disgust-inducing, fear-inducing and neutral scenes. Afterwards, the patients rated the intensity of the induced disgust, fear and OCD symptoms. The responses were compared with those of 10 healthy control subjects. The disorder-relevant pictures provoked intense OCD symptoms in the clinical group associated with increased activation in the bilateral prefrontal cortex, the left insula, the right supramarginal gyrus, the left caudate nucleus and the right thalamus. The patients gave higher disgust and fear ratings than the controls for all aversive picture categories. Neural responses towards the disorder-irrelevant disgusting and fear-inducing material included more pronounced insula activation in patients than controls. Summarizing, photos of individual OCD-triggers are an effective means of symptom provocation and activation of the fronto-striato-thalamo-parietal network. The increased insular reactivity of OCD patients during all aversive picture conditions might mirror their susceptibility to experience negative somatic states.
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Patients suffering from obsessive-compulsive disorder (OCD) are characterized by dysregulated neuronal processing of disorder-specific and also unspecific affective stimuli. In the present study, we investigated whether generic fear-inducing, disgust-inducing, and neutral stimuli can be decoded from brain patterns of single fMRI time samples of individual OCD patients and healthy controls. Furthermore, we tested whether differences in the underlying encoding provide information to classify subjects into groups (OCD patients or healthy controls). Two pattern classification analyses were conducted. In analysis 1, we used a classifier to decode the category of a currently viewed picture from extended fMRI patterns of single time samples (TR=3s) in individual subjects for several pairs of categories. In analysis 2, we used a searchlight approach to predict subjects' diagnostic status based on local brain patterns. In analysis 1, we obtained significant accuracies for the separation of fear-eliciting from neutral pictures in OCD patients and healthy controls. Separation of disgust-inducing from neutral pictures was significant in healthy controls. In analysis 2, we identified diagnostic information for the presence of OCD in the orbitofrontal cortex, and in the caudate nucleus. Accuracy obtained in these regions was 100% (p<10(-6)). To summarize our findings, by using multivariate pattern classification techniques we were able to identify neurobiological markers providing reliable diagnostic information about OCD. The classifier-based fMRI paradigms proposed here might be integrated in future diagnostic procedures and treatment concepts.
Erkunden
Team
- Vaitl (3)
Eintragsart
Sprache
- Englisch (3)
Thema
- Middle Aged
- Adult (3)
- Analysis of Variance (1)
- Anxiety/psychology (1)
- Cerebrovascular Circulation/physiology (1)
- *Emotions (1)
- Emotions/*physiology (1)
- Fear/*physiology (1)
- Female (3)
- Hemodynamics/physiology (1)
- Humans (3)
- *Magnetic Resonance Imaging (1)
- Magnetic Resonance Imaging (1)
- Male (3)
- Mental Disorders/*epidemiology/*psychology (1)
- Obsessive-Compulsive Disorder/*diagnosis/*physiopathology (1)
- Obsessive-Compulsive Disorder/*physiopathology/psychology (1)
- Pattern Recognition, Automated (1)
- Personality (1)
- Photic Stimulation (1)
- Psychiatric Status Rating Scales (1)
- *Surveys and Questionnaires (1)
- Surveys and Questionnaires (1)