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This micro-phenomenological study examines altered states of consciousness (ASC) during Floatation-REST, a sensory isolation method where individuals lie in a tank filled with Epsom salt-saturated water in complete silence and darkness. Salubrious effects of Floatation-REST have been shown in persons suffering from mental health conditions; these positive outcomes might be related to the experience of ASC. Micro-phenomenological interviews were conducted with fourteen participants who completed a 60-minute Floatation-REST session, to capture the generic structure of ASC. We found that most participants experience four distinct phases during a session (diachronic structure): after an initial acclimatization phase (1), participants experience a transitional phase (2) that prepares them for a subsequent ASC phase (3), followed by a phase of temporal and spatial reorientation (4). The ASC phase is characterized by the experience of positive emotions, deep relaxation, a loss of orientation in space and time, and a reduction in bodily sensations and thoughts (synchronic structure). The characteristics of the ASC phase emerge gradually and progressively intensify. This micro-phenomenological analysis of Floatation-REST sheds new light on the potential of this therapeutic technique. We discuss possible future research and therapeutic applications of Floatation-REST.