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Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias
Eintragsart
Autoren/Mitwirkende
- Mashour, George A. (Autor)
- Frank, Lori (Autor)
- Batthyany, Alexander (Autor)
- Kolanowski, Ann Marie (Autor)
- Nahm, Michael (Autor)
- Schulman-Green, Dena (Autor)
- Greyson, Bruce (Autor)
- Pakhomov, Serguei (Autor)
- Karlawish, Jason (Autor)
- Shah, Raj C. (Autor)
Titel
Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias
Zusammenfassung
Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that paradoxical lucidity, if systematically confirmed, challenges current assumptions and highlights the possibility of network-level return of cognitive function in cases of severe dementias, which can provide insight into both underlying neurobiology and future therapeutic possibilities.
Publikation
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Band
15
Ausgabe
8
Seiten
1107-1114
Datum
2019
Zeitschriften-Abkürzung
Alzheimers Dement
Sprache
eng
ISSN
1552-5279
Kurztitel
Paradoxical lucidity
Bibliothekskatalog
PubMed
Zitierung
Mashour, G. A., Frank, L., Batthyany, A., Kolanowski, A. M., Nahm, M., Schulman-Green, D., Greyson, B., Pakhomov, S., Karlawish, J., & Shah, R. C. (2019). Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 15(8), 1107–1114. https://doi.org/10.1016/j.jalz.2019.04.002
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Thema
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